Felodipine Sandoz Special Precautions

The efficacy and safety of felodipine in the treatment of hypertensive emergencies has not been studied.
Concomitant administration of medicinal products that strongly induce or inhibit CYP3 A4 enzymes result in extensively decreased or increased plasma levels of felodipine, respectively. Therefore such combinations should be avoided.
Mild gingival enlargement has been reported in patients with pronounced gingivitis/periodontitis. The enlargement can be avoided or reversed by careful oral hygiene.
Felodipine, like other effective arteriolar dilators, may in rare cases precipitate significant hypotension which in susceptible individuals may result in myocardial ischaemia.
Effects on ability to drive and use machines: Felodipine has minor or moderate influence on the ability to drive and use machines. If patients taking felodipine suffer from headache, nausea, dizziness or fatigue and ability to react may be impaired. Caution is recommended especially at the start of treatment.